BD 231601 - Disk Susceptibility Sensi-Disc Trimethoprim 5mcg Precision AST Disk for Antifolate Antibiotic Testing, 10/BX
The BD 231601 Disk Susceptibility Sensi-Disc Trimethoprim 5mcg is a high-performance antimicrobial susceptibility testing (AST) reagent designed for evaluating bacterial sensitivity to trimethoprim, an antifolate antibiotic widely used in treating urinary tract infections and other Gram-negative and Gram-positive bacterial diseases. Each sterile paper disk contains 5 micrograms of trimethoprim, delivering a standardized antibiotic diffusion gradient for accurate zone interpretation using the Kirby-Bauer disk diffusion method. BDs stringent manufacturing ensures consistency, quality, and reproducibility across every test.
| Manufacturer | Application | Storage Requirements |
| 231601 | Antimicrobial Susceptibility Testing Disc | Requires Refrigeration |
Key Benefits
The BD 231601 Trimethoprim 5mcg Sensi-Disc provides reliable potency, consistent diffusion, and clearly defined inhibition zonescritical for accurate identification of resistant organisms. These sterile, single-use disks minimize contamination risks and maintain consistent test performance. Trimethoprims activity depends on precise antibiotic distribution, and BDs engineering ensures dependable zone formation for laboratories monitoring resistance patterns and guiding targeted therapy.
Compatibility and Applications
This Sensi-Disc is compatible with standard Mueller-Hinton agar and adheres to CLSI and EUCAST disk diffusion guidelines. It is commonly used for testing:
- Escherichia coli
- Klebsiella species
- Proteus mirabilis
- Staphylococcus species (when appropriate guidelines are followed)
Trimethoprim susceptibility testing is especially relevant in urinary tract pathogens, community-acquired infections, and resistance surveillance studies.
Usage Guidelines
Prepare a bacterial suspension equivalent to a 0.5 McFarland standard and inoculate a Mueller-Hinton agar plate uniformly. Using sterile forceps or a disk dispenser, place the BD 231601 Trimethoprim 5mcg disk onto the agar surface. Incubate plates at 3537C for 1620 hours. After incubation, measure the inhibition zone diameter in millimeters and interpret results according to current CLSI or EUCAST breakpoints. Store disks at 28C in sealed containers with desiccants to maintain potency and avoid moisture exposure.
Certifications, Safety Standards, and Regulatory Approvals
The BD 231601 Sensi-Disc is produced in ISO 9001 and ISO 13485 certified facilities and complies with FDA and CE requirements for in vitro diagnostic (IVD) use. Each production lot is tested for potency, diffusion uniformity, sterility, and stability, ensuring accurate performance aligned with CLSI M100 standards for susceptibility testing.
Comparison with Competitor Products
BD Sensi-Discs outperform many generic susceptibility disks in stability, potency retention, and consistent antibiotic diffusion. Competitor disks may show variable drug loading or inconsistent inhibition zones, leading to inaccurate or unreliable susceptibility results. BDs advanced formulation and moisture-resistant packaging ensure predictable and reproducible outcomes.
Typical User Profile and Application Scenarios
This disk is ideal for microbiologists, diagnostic laboratory technologists, infectious disease specialists, and researchers involved in antimicrobial resistance studies. Common applications include:
- Routine AST panels in clinical microbiology labs
- Urinary pathogen resistance profiling
- Surveillance of trimethoprim resistance in community-acquired infections
- Research examining antifolate mechanisms and antimicrobial interactions
Best Practices for Use and Maintenance
Use sterile forceps to handle disks and avoid touching the antibiotic surface. Allow refrigerated disks to reach room temperature before opening the container to prevent condensation. Verify performance with quality control strains such as E. coli ATCC 25922. Always store disks in original packaging and do not use expired or compromised disks. Dispose of used disks and inoculated plates as biohazard waste.
Regulatory and Safety Information
The BD 231601 Trimethoprim 5mcg disk is intended for in vitro diagnostic use by trained laboratory staff. All procedures involving clinical isolates must follow biosafety level 2 practices. Appropriate PPEgloves, lab coat, protective eyewearshould be used. Dispose of all contaminated materials in accordance with institutional and regulatory biosafety guidelines.
How to Order
To order the BD 231601 Disk Susceptibility Sensi-Disc Trimethoprim 5mcg, add the product to your cart and complete checkout through CIA Medicals secure online ordering system. For bulk purchasing, laboratory contracts, or technical assistance, contact CIA Medical customer service at (312) 275-5850 or use the inquiry form on this page. Our team is available to assist with availability, pricing, and product specifications.
