BD 231753 - Disk Susceptibility Sensi-Disc Ceftazidime/Clavulanic Acid 30/10mcg -Lactamase Inhibitor Combination AST Disc,PK
The BD 231753 Disk Susceptibility Sensi-Disc Ceftazidime/Clavulanic Acid is a high-precision antimicrobial susceptibility testing (AST) disc used to detect -lactamasemediated resistance mechanisms, particularly extended-spectrum -lactamases (ESBLs) in Gram-negative bacteria. Each sterile disc contains 30mcg of ceftazidime combined with 10mcg of clavulanic acid, a -lactamase inhibitor that restores ceftazidime activity in ESBL-producing organisms. Designed for the Kirby-Bauer disk diffusion method, this Sensi-Disc provides reliable, reproducible inhibition zones that support accurate interpretation of ESBL phenotypes in clinical laboratories.
| Manufacturer | 231753 |
| Application | Antimicrobial Susceptibility Testing Disc |
| Storage Requirements | Requires Refrigeration |
Key Benefits
The BD 231753 Ceftazidime/Clavulanic Acid disc offers superior potency stability and consistent diffusion, producing clear differentiation between ESBL-positive and ESBL-negative strains. The sterile, single-use format eliminates contamination risk while ensuring precise antibiotic delivery. BDs rigorous quality controls guarantee lot-to-lot consistency, enabling clinicians to trust AST results when diagnosing resistant infections and selecting effective therapies.
Compatibility and Applications
This disc is compatible with standard Mueller-Hinton agar and follows CLSI and EUCAST guidelines for ESBL confirmatory testing. It is commonly used with:
- Escherichia coli
- Klebsiella pneumoniae and related species
- Proteus mirabilis
- Other Enterobacterales being screened for ESBL production
Clinical applications include:
- Confirmatory ESBL phenotypic testing
- Routine AST in hospital microbiology labs
- Infection-control screening for antimicrobial-resistant organisms
- Antibiotic stewardship programs monitoring resistance trends
Usage Guidelines
Prepare a 0.5 McFarland standard bacterial suspension and inoculate a Mueller-Hinton agar plate evenly. Apply the BD 231753 disc using sterile forceps or an automated disc dispenser. Incubate at 3537C for 1620 hours. Compare zone diameter with a ceftazidime disc alone to evaluate clavulanic acid synergy. A =5mm increase in zone size typically indicates ESBL production (per CLSI guidelines). Store discs at 28C in moisture-protective packaging.
Certifications, Safety Standards, and Regulatory Approvals
This Sensi-Disc is produced in ISO 9001 and ISO 13485 certified facilities and complies with FDA and CE requirements for in vitro diagnostic (IVD) devices. Each lot is validated for antibiotic content, diffusion accuracy, sterility, and shelf-life stability to ensure dependable ESBL confirmatory testing.
Comparison with Competitor Products
BD Sensi-Discs deliver more consistent inhibition zones and superior stability compared with many generic combination AST discs. Competitor products often show variable clavulanic acid content, leading to inconsistent synergy results and unreliable ESBL detection. BDs advanced manufacturing ensures uniform antibiotic distribution, accurate potency, and high-clarity diffusion patterns essential for precise phenotypic confirmations.
Typical User Profile and Application Scenarios
This product is used by clinical microbiologists, diagnostic laboratory specialists, infectious-disease teams, and research laboratories. It is particularly valuable for:
- Routine ESBL surveillance testing
- Diagnostic evaluation of multidrug-resistant Gram-negative infections
- Hospital outbreak tracking and infection-control investigations
- Teaching laboratories focusing on -lactamase resistance mechanisms
Best Practices for Use and Maintenance
Allow discs to reach room temperature before opening to prevent condensation. Handle only with sterile forceps and avoid prolonged exposure to ambient humidity. Use approved quality-control strains such as E. coli ATCC 25922 (susceptible) and Klebsiella pneumoniae ATCC 700603 (ESBL positive). Discard expired or moisture-exposed discs, as potency loss may compromise ESBL detection accuracy.
Regulatory and Safety Information
The BD 231753 Sensi-Disc is intended for in vitro diagnostic use by trained laboratory personnel. Follow biosafety level 2 practices when handling clinical isolates and dispose of all used discs, plates, and materials as regulated biohazard waste according to institutional and governmental guidelines.
How to Order
To order the BD 231753 Disk Susceptibility Sensi-Disc Ceftazidime/Clavulanic Acid, add the item to your cart and complete checkout through CIA Medicals secure online ordering system. For bulk orders, supply contracts, or additional assistance, contact CIA Medical customer service at (312) 275-5850 or submit an inquiry using the form on this page. Our support team is available to answer questions and provide documentation as needed.
